Every multicellular creature -; whether soaring through the skies, swimming in the ocean's depths or roaming the earth's surface -; shares a common vulnerability: the uncontrolled growth of cells known as cancer.
Arizona State UniversityOct 29 2024 Every multicellular creature -; whether soaring through the skies, swimming in the ocean's depths or roaming the earth's surface -; shares a common vulnerability: the uncontrolled growth of cells known as cancer.
The study adds nuance to Peto's paradox by showing that cancer prevalence tends to increase with body size and cellular mutation rates but decreases with longer gestation periods. This suggests that the relationship between size, longevity and cancer resistance is more intricate than previously understood. The results deepen our understanding of cancer evolution and could provide clues for developing more effective therapies.
In addition to his ASU colleagues, Maley is joined by an interdisciplinary team from leading U.S. and international research institutions. The study appears in the current issue of the journal Cancer Discovery. Related StoriesMammals generally showed the highest rates of both benign and malignant tumors, followed by reptiles, birds and amphibians. These results highlight the complex relationship between an animal's traits -; such as body size, lifespan and reproductive timing -; and its cancer risk.
Another key finding is that species with longer gestation periods tend to have lower cancer rates. Researchers hypothesize that longer gestational times may provide more opportunities for cells to regulate themselves properly, reducing the likelihood of high-impact mutations that could lead to cancer later in life.
Cancer Prevention Cell DNA DNA Damage Evolution Malignant Mutation Research Swimming
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