The American College of Physicians updated its existing guidelines to incorporate evidence on the new treatments for type 2 diabetes.
Type 2 diabetes is the most common form of diabetes, representing more than 90% of all cases worldwide. The prevalence of T2D is increasing globally, mainly because of behavioral and social factors related to obesity, diet, and physical activity. The International Diabetes Federation estimated inthat 537 million adults between the ages of 20 and 79 years have been diagnosed with diabetes worldwide. The organization predicts an increase to 643 million by 2030 and 743 million by 2045.
Compared with DPP-4 inhibitors, SGLT-2 inhibitors probably reduce MACE, as well as compared with sulfonylureas. Compared with usual therapy, DPP-4 inhibitors do not result in differences in all-cause mortality, MACE, myocardial infarction, stroke, hospitalization for chronic heart failure , CKD progression, or severe hypoglycemia. Compared with SGLT-2 inhibitors, DPP-4 inhibitors may increase hospitalization due to CHF and probably increase the risk for MACE and CKD progression. Compared with GLP-1 agonists, they probably increase all-cause mortality and hospitalization due to CHF and the risk for MACE.
Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D SGLT2 Inhibitors Sodium-Glucose Transporter-2 Inhibitors Sodium-Glucose Co-Transporter-2 Inhibitors Sodium-Glucose Cotransporter-2 Inhibitors Clinical Guidelines Guidelines Dpp-4 Inhibitors Dipeptidyl Peptidase-4 Inhibitors
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