Exploring the potential of GFET-based biosensors for rapid, sensitive detection of biological analytes, including COVID-19.
By Arzoo PuriJun 6 2024Reviewed by Lexie Corner Graphene field effect transistor -based biosensors have gained significant interest due to their superior stability and higher electron mobility. This article discusses the design, applications, and limits of GFET-based biosensors. Introduction to GFTEs in Biosensors A field effect transistor is a carrier device with three terminals: source, drain, and gate.
Graphene's high conductivity allows for very short response times, aiding in rapid detection of the target analyte.4 In the first fabrication method, biological receptors are attached to the graphene surface to detect targets by mutual forces. Charge transfer modifies the conductivity following specific binding, transforming metabolic changes into detectable electrical signals.
Seo et al. reported the use of a graphene sheet as the sensing region combined with a spiked antibody against severe-acute-respiratory-syndrome-related coronavirus to detect the virus in clinical specimens using a FET biosensor. This method successfully identified the 100 fg/mL SARS-CoV-2 spike protein within the clinical transport media.7
Ahn et al. created GFET-based dual biological electronic tongues that simultaneously detect umami and sweet tastes.10 This innovation opens new avenues for replicating complex human biomimetic systems and highlights the potential of GFET-based biosensors. Reagents like bovine serum albumin , polyethylene glycol , and surfactants are often used to block the graphene surface, reducing hydrophobic interactions and preventing non-specific binding.11
Further studies on the nano-bio interfaces in GFET sensors are needed. A comprehensive analysis of stability and real-time detection is essential to commercialize GFET biosensors, ensuring long-term stability and high performance for clinical use.8References and Further Reading 1. Liang, Q-H., et al. . The Application of Graphene Field-Effect Transistor Biosensors in COVID-19 Detection Technology: A Review. Sensors. doi.org/10.
5. Thriveni, G., Ghosh, K. . Advancement and Challenges of Biosensing Using Field Effect Transistors. Biosens. doi.org/10.3390/bios12080647
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
What is a Graphene Field Effect Transistor?Graphene Field Effect Transistors (GFETs) show promise for future electronics. They offer high-speed performance, enhanced sensitivity, and applications in biosensing, flexible devices, and more.
Read more »
Kevin Costner's Field of Dreams co-star makes surprising comment about his 'paternal energy'Field of Dreams starred Kevin as a young father who builds a baseball field
Read more »
Graphene-Based Electron Microscopy GridsGraphene grids enhance electron microscopy imaging with high uniformity, inertness, and mechanical strength, ideal for high-resolution biological samples.
Read more »
A protein-based risk score for hip-fracture using an aptamer-based proteomic platformAn international team of medical researchers has developed a protein-based risk score for hip fracture using an aptamer-based proteomic platform. In their study, published in the journal Nature Aging, the group analyzed data from the Cardiovascular Health Study and used their findings to develop their scoring system.
Read more »
Study introduces hyperspectral dark-field microscopy for rapid and accurate identification of cancerous tissuesBreast-conserving surgery (BCS), also called lumpectomy, involves the removal of a cancerous lump and some surrounding tissue. BCS is suitable for women with early-stage breast cancer or small lumps, as it preserves more of the breast compared to mastectomy.
Read more »
Leeds Rhinos' next opponents Hull FC sign overseas duo 'with immediate effect'Super League strugglers Hull FC have signed two players from Australia’s NRL ahead of next weekend’s clash with Leeds Rhinos.
Read more »