Vitamin D protects against H1N1 and SARS-CoV-2 infection in mice Coronavirus Disease COVID H1N1 SARSCoV2 VitaminD biorxivpreprint
A recent study published on the bioRxiv* preprint server reports that vitamin D deficiency enhances disease severity, while adequate vitamin D supplementation reduces inflammation, after H1N1 and severe acute respiratory syndrome coronavirus infections in mice.
Lung epithelial cells express the vitamin D receptor and are regulated by 1,25D supplementation. Thus, vitamin D treatment has been shown to directly affect the lung epithelium and reduce the inflammatory response within the lungs. Although all mice infected with H1N1 experienced respiratory distress seven days after infection, D+WT mice experienced the least amount of respiratory distress. All symptoms of respiratory distress in both WT and Cyp KO mice receiving vitamin D supplementation were resolved by day 10. Comparatively, both D-WT and D-Cyp KO continued to experience greater symptoms of respiratory distress that did not completely resolve by day 14.
Vitamin D supplementation and SARS-CoV-2 Related StoriesSARS-CoV-2 infection and the effects of vitamin D supplementation were assessed in mice expressing the human angiotensin-converting enzyme 2 receptor, which is the receptor utilized by SARS-CoV-2 to gain entry into cells. Since Cyp27B1 remained present in this mouse strain, some mice were given a vitamin D deficient chow for eight weeks prior to infection to induce a state of vitamin D deficiency.
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