Wearable sweat sensor detects molecular hallmark of inflammation Caltech natBME
One of these markers, the C-reactive protein, or CRP, which is secreted by the liver, is so commonly associated withthat its presence in the bloodstream is a strong indicator of an underlying health condition.
The paper describing the work,"A wireless patch for the monitoring of C-reactive protein in sweat," appears in the June 22 issue of the journalWei Gao, whose lab is responsible for the development of a variety of wearable sweat sensors, including this latest one, says CRP is much more difficult to detect than the molecules detected by his other sweat sensors. One reason is that CRP is present in the blood at a much lower concentration than other biomarkers.
This CRP sensor, like other sensors developed by Gao and his team, is built upon laser-engraved graphene, a sheet-like form of carbon. The graphene structure contains many tiny pores that create a large amount of surface area. Those pores are embedded with antibodies that bind to CRP and special molecules capable of generating a small electric current under certain conditions.that carry with them a separate set of CRP antibodies .
Because each gold nanoparticle contains multiple detector antibodies, they amplify the minuscule signal that a single CRP molecule would otherwise provide, Gao says.To account for the influence of variations in sweat compositions from person to person on the electrochemical signal of the, the sensor was also designed to measure the concentration of ions in the sweat, the sweat's pH, and skin temperature.
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