Which GI Side Effects Should GLP-1 Prescribers Worry About?

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Which GI Side Effects Should GLP-1 Prescribers Worry About?
Diabetes Mellitus Type IiType 2 DiabetesType 2 DM
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Dr David Johnson identifies the gastrointestinal adverse events most closely associated with these popular medications, based on his review of the latest data.

-like peptide 1 receptor agonists for the treatment of diabetes and weight loss has led to a corresponding interest in their potential side effects . Several recent studies have sought to expound upon what role, if any, GLP-1 RAs may have in increasing the risk for specific gastrointestinal adverse events.

In the absence of sufficient evidence, these groups suggested that healthcare providers"exercise best practices when performing endoscopy on these patients on GLP-1 ." They called for more data and encouraged key stakeholders to work together to develop the necessary evidence to provide guidance for these patients prior to elective endoscopy.

Although relatively infrequent, the risk for GI adverse events should be given special consideration by providers when prescribing them for weight loss, because the risk/benefit ratios may be different from those in patients with diabetes. on clinical, biochemical, and histologic markers in patients with metabolic dysfunction–associated steatotic liver disease . These favorable changes are evident by reductions in the hepatic cytolysis markers .

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