A new study compares the competing weight-loss medications Wegovy and Zepbound, and a clear winner emerges.
ith more people taking the weight-loss drugs Wegovy and Zepbound, one question inevitably arises: which one is more effective?, Lilly announced that in its latest trial comparing its medication, Zepbound, to Wegovy, made by Novo Nordisk, people randomly assigned to receive Zepbound lost about 20% of their body weight after about 18 months, while those taking Wegovy lost nearly 14% of their body weight.
Wegovy and Zepbound both target a group of hormones that the body makes called incretins. Wegovy works on the GLP-1 hormone, which suppresses appetite and signals the pancreas to produce insulin to break down sugars in food. Zepbound works on both GLP-1 and GIP, another hormone that stimulates insulin production.
The results are in line with past studies each pharmaceutical company conducted to earn approval from the U.S. Food and Drug Administration, but the direct comparison could encourage more development of medications that target multiple hormones, in order to achieve greater weight loss and potentially other health benefits. Lilly is developing a drug that targets three hormones: the two incretin hormones, GLP-1 and GIP, and glucagon.
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