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Throughout human history, different infectious diseases have taken the mantle of"most deadly disease" infecting humans.outbreaks – to name a few. Some have lasted for centuries and persist today, such as tuberculosis. Others are often thought of as being consigned to the history books.
The first occurred from the fifth to the seventh century, killing about 15 million people in the Mediterranean basin, and heavily affecting the Byzantine, Sasanian and Roman empires. However, from the 1960s onwards, cases dropped dramatically, and the bubonic plague is not often considered a modern disease. Despite this,Although no longer common in many parts of the world, the bubonic plague still exists in geographic pockets and can spread in communities if the right mix of conditions are present.of the body as the main site of infection: pneumonic is mainly lung-based, septicemic is mainly blood-based, and bubonic is mostly in the lymph nodes.
This transmission from rodents to humans takes place via fleas. These insects bite the rats and afterwards may jump and bite a human, injecting the plague bacterium into the lymphatic system of the human. The bacteria then travel through this system to the lymph nodes and infection begins.. These swollen nodes, called buboes, can cause the tissue around them to turn black and die. They may also burst open, releasing the pus inside.
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