A new study reveals that young patients treated with psychiatric medications receive potentially dangerous combinations with concerning frequency.
Rutgers UniversitySep 6 2024
Good practice demands that patients and caregivers be informed of and assent to risks and benefits, including informing them that the intended pair of medications is typically contraindicated." Polypharmacy is very common, with nearly 38 percent of patients in the study filling two or more medications with at least one month overlap, generating more than 11,000 distinct drug combinations.
Other common risky combinations involved antidepressants such as fluoxetine and trazodone paired with various antipsychotic medications, risking life-threatening QT interval prolongation and serotonin syndrome. Contraindicated combinations were more common in adolescents and young adults than younger children, with no children under 6 receiving risky combinations. While boys were more likely to receive any mental health medication, there was no gender difference in potentially dangerous pair usage.
Antipsychotic Children Frequency Medicaid Medical School Mental Health Pediatrics Primary Care Research Serotonin Syndrome
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