The USphere Series of microbubble contrast agents, designed for preclinical imaging, operates efficiently at 1-40 MHz frequencies. With a small size distribution (1.1-1.4 µm) and high concentration, they are suitable for various species, including mice, rats, rabbits, and non-human primates. The agents support perfusion imaging, biomarker targeting, multi-modal imaging with fluorescent dyes, and applications in drug delivery and gene transfection. Rigorously tested on the Prospect T1 system, they excel in linear and harmonic contrast imaging, offering detailed perfusion insights for tumor, abdominal organ imaging, and drug development studies.
The USphere Series of microbubble contrast agents has been carefully designed for preclinical imaging, operating efficiently at frequencies ranging from 1 to 40 MHz. Their small size distribution and high concentration render them exceptionally suitable for application across various species, including mice, rats, rabbits, and non-human primates.
A diverse array of agents are available: for imaging perfusion, targeting specific biomarkers, as well as agents containing fluorescent dyes for multi-modal imaging, and those intended for targeted drug delivery or gene transfection - among others. The USphere Series of microbubble contrast agents has been meticulously crafted for application across various species used in preclinical research, including mice, rats, rabbits, and even pigs; these agents have been rigorously tested and demonstrated effective performance at frequencies ranging from 1 to 40 MHz.
In particular, these agents have undergone testing on the Prospect T1 high-frequency ultrasound system, where they have shown commendable performance in both linear and harmonic contrast imaging modes. A diverse array of bubble configurations is available, some designed specifically for studying perfusion, others to assist in biomarker detection, and yet others for facilitating ultrasound-mediated drug or gene delivery, along with more sophisticated theranostic applications.
The critical factors influencing the particle size of the microbubble have been determined; through precise adjustments to the lipid formulation, the USphere agents have been engineered to achieve the smallest size distribution compared to competitors in the current market. Microbubble contrast agents are capable of visualizing all levels of vasculature, offering detailed perfusion information that may be pertinent in tumor and abdominal organ imaging, as well as in drug development studies, to name just a few.
When handling small animals like mice or rats, the recommended injection volume is minimal enough to avoid overloading the circulatory system, while still providing an adequate amount of microbubbles to achieve the intended contrast enhancement. Additionally, further dilution of the microbubbles can be performed using sterile saline to facilitate more precise delivery of limited quantities of microbubbles. To enable precise perfusion properties of the microvasculature, the microbubbles must be nanoscale in size.
The microbubbles' stability for a duration of three days enables the user to conduct the necessary studies within that timeframe, making full use of the entire volume of the agent and preventing the wastage of any excess agent that cannot be utilized. The microbubbles are applicable to a diverse range of species, including mice, rats, rabbits, non-human primates, and pigs.
The microbubbles have been utilized across a broad spectrum of ultrasound systems from different manufacturers, employing both linear and non-linear/harmonic contrast imaging modes. USphere Prime agents consist of gas-filled microbubbles encased in a phospholipid shell. The small size distribution enables these microbubbles to navigate effortlessly through all tiers of the vascular system, including the capillaries.
USphere Labeler agents have been functionalized with various moieties, including biotin, avidin, and/or streptavidin, enabling the incorporation of specific targeting agents like small molecules and antibodies. These agents can be tailored to target particular biomarkers of interest. The USphere Tracer agents, along with the USphere Labeler featuring Fluorescence, have been enhanced to incorporate a fluorescent dye, enabling multi-modal imaging with a fluorescence imaging system. The USphere Trans+ agents have been modified to possess a positively charged surface.
These microbubbles are capable of delivering a substantial payload, thereby enhancing the targeting, effectiveness, and simplicity of drug delivery and gene transfection compared to conventional methods. To start a conversation, please log into your AZoProfile account first, or create a new account. I understand, and agree to receive occasional emails about Azthena such as usage tips and new feature announcements. While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses.
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Microbubble Contrast Agents Preclinical Imaging Drug Delivery Gene Transfection Ultrasound Imaging
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