Researchers develop a new open-source software tool called clipping spline that allows for unprecedented visualization of 3D images. The software uses thin plate spline (TPS) technology to create interactive and dynamic cutaway views of complex structures, enabling the analysis of previously unseen dynamics in embryonic mouse heart development.
Researchers have developed a new software tool called clipping spline that provides unprecedented capabilities to see inside 3D images. The interactive, dynamic cutaway views allowed them to analyze never-before-seen dynamics of embryonic mouse heart development using optical coherence tomography (OCT) images. \The researchers describe their new open-source software tool in the Optica Publishing Group journal Biomedical Optics Express.
It is a user-friendly tool to visualize complex structures, such as a tubular structure that curves in 3D, in a single cutaway view. \The software leverages a type of smooth surface known as the thin plate spline (TPS) and applies it to volume clipping for the first time. The TPS is a 3D surface defined by a set of control points in the way that it intersects all the control points with minimal curvature. This intuitive and adjustable surface allows users to move, add or delete control points to refine its shape and position interactively, allowing it to be adapted to complex structures. \The researchers used the clipping spline to visualize and analyze embryonic mouse heart development with OCT data, for example, tracking myocardial dynamics over 12.8 hours of development across 712 time points. The clipping spline allowed them to see multiple parts of the convoluted heart tube at the same time in a single view, providing a larger view of the dynamics than was available previously. This gave them a better picture of how the biomechanics of the embryonic heart are involved in generating specific blood flow patterns. They also used the clipping spline to uncover how the inflow tracts of the early heart merge to form the sinus venosus, a structure that directs blood into the developing heart. \The researchers say that the clipping spline is ready to be widely used by the biomedical imaging community. They are now focused on developing advanced image processing methods using the clipping spline and applying the clipping spline to further investigate the dynamics and processes of embryonic heart development
EMBRYONIC HEART DEVELOPMENT 3D IMAGING OPTICAL COHERENCE TOMOGRAPHY SOFTWARE TOOL BIOMEDICAL ENGINEERING
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