Are Nanoparticle Coatings the Solution to Next Generation Stents? cardiovascular stent nanocoatings nanomaterials alloy
By Dr. Priyom Bose, Ph.D.Aug 24 2022Reviewed by Megan Craig, M.Sc. Since the first application of stents for the treatment of blocked coronary arteries, many technological advancements have occurred, such as the introduction of bioabsorbable magnesium alloys, to improve clinical outcomes. Cardiovascular stent technology, related to the design, materials, coating, and many other relevant features, is evolving continuously.
Evolution of Stent Technology The development of drug-eluting stents is considered a key achievement in stent technology, as it has significantly decreased restenosis from 20-30% to 3-20% . DES technology involves coating the stent scaffolds with a drug containing permanent polymers.
Dexamethasone is a therapeutic agent that possesses anti-inflammatory properties and inhibits smooth muscle cell proliferation. Application of Dexa in DES technology exhibited satisfactory clinical outcomes. The evaluation of the material's surface characteristics revealed that the surface roughness of the coating of the nanoparticles was around 700 nm, which contributed to its enhanced surface hydrophobicity. To analyze the drug release property, researchers compared the releasing property of two groups of samples, i.e., WE43 and stainless steel. Releasing profile exhibited that 25% of Dexa was released within the first five hours.
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Diverse leadership is more than skin deep. Figureheads need to be relatableCOMMENT: Diverse leadership is more than skin deep. Figureheads need to be relatable, says Denise Myers
Read more »
Versatile Catalysts for Next-Generation Zn-Air BatteriesThe creation of cost-effective electrocatalytic nanostructures for effective oxygen reducing reaction (ORR) and oxygen evolution reaction (OER) via functional and morphology control is a significant obstacle for prospective power storage applications.
Read more »
Improving Dolutegravir Delivery For Pediatric HIV PatientsNew research presents the fabrication of Dolutegravir-loaded chitosan nanoparticles with improved solubility and bioavailability for the treatment of pediatric HIV patients
Read more »
Nanomedicine Specifically Targets Triple-Negative Breast CancerResearchers discussed the utility of neutrophil cell membrane coating of a self-assembly nanoconstruct to enable high specificity for triple-negative breast cancer treatment.
Read more »
Sean Paul adds Liverpool gig to huge Scorcha UK tour 2022The singer is making his way to Liverpool next month 🙌 aff
Read more »
Emily Ratajkowski gave herself a haircut and filmed the whole thing“Is this insane, am I being crazy?”
Read more »