B cells can control responses of myeloid cells through the release of particular cytokines (small proteins that control the growth and activity of cells in the immune system), challenging the prevailing view that T cells are the principle orchestrators of immune responses.
B cells drive responses of other immune cells, and can be modified to prevent Multiple Sclerosis symptomsB cells can control responses of myeloid cells through the release of particular cytokines , challenging the prevailing view that T cells are the principle orchestrators of immune responses.
A healthy immune system is always responding to stimuli by activating or suppressing immune responses, in part through release of different cytokines which tell other cell types how to respond. Normally, every immune response generates a counter response, and this constant"push-me-pull-you" helps maintain the proper balance between immune responses.
"An exciting approach for new MS treatments, then, might be to partially mute respiration in B cells, which could then stop the cascade of interactions between immune cells that drives inflammation and MS activity," said Bar-Or. This research was funded primarily by the Melissa and Paul Anderson Gift Fund and the National Institutes of Health Autoimmunity Center of Excellence with partial support also from the Children's Hospital of Philadelphia Center for Mitochondrial and Epigenomic Medicine grant, a grant from the National Natural and Science Foundation of China and a sponsored research agreement between The University of Pennsylvania and Biogen.Rui Li, Yanting Lei, Ayman Rezk, Diego A.
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