Bispecific antibody shows improved efficacy against SARS-CoV-2 variants Antibody BispecificAntibody Efficacy SARSCoV2 Coronavirus Disease COVID MDAndersonNews
By Dr. Chinta SidharthanMar 14 2023Reviewed by Danielle Ellis, B.Sc. *Important notice: bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Background Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy SARS-CoV-2 is an enveloped, single-stranded ribonucleic acid virus that enters the mammalian host cells through interactions between the RBD in the S1 subunit of the spike protein and angiotensin-converting enzyme-2 receptor in the mammalian cell. Transmembrane serine protease 2 present in the mammalian cell aid the viral entry by cleaving the spike protein.
About the study The present study used single B cell cloning and humanized transgenic mice to generate monoclonal antibodies that could bind and neutralize multiple SARS-CoV-2 variants. Female ATX-GK mice were immunized subcutaneously with spike protein dissolved in phosphate-buffered saline along with an adjuvant and administered one booster shot every week for three weeks.
Results The results reported that the two selected monoclonal antibodies — SARS-CoV2-83 and SARS-CoV2-81 — were able to bind to multiple SARS-CoV-2 variants, including the Omicron variant with moderate to strong affinities. The two monoclonal antibodies were not, however, able to bind to one of the mutants of the Delta variant.
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