Research reveals advanced brain aging in older adults correlates with cognitive decline and Alzheimer's risk, highlighting the need for early intervention.
By Dr. Chinta SidharthanReviewed by Lily Ramsey, LLMOct 24 2024 New study uncovers how advanced brain age, even in cognitively healthy adults, signals a higher risk of Alzheimer's disease and cognitive decline, offering insights into early detection and potential prevention strategies.
Brain health can be estimated using the difference between a person's predicted brain age and their actual age. A brain that appears older than its chronological age could indicate underlying health issues. Despite this growing evidence on brain aging and neurological health, there is a dearth of research on whether advanced brain age in older adults without other cognitive impairments increases the risk of neurodegenerative conditions such as Alzheimer's disease.
The researchers used two datasets for the study. The first set consisted of close to 3,500 participants between the ages of 40 and 85 years, spanning four different studies, including the United Kingdom Biobank. Furthermore, genetic data involving Alzheimer's disease-related single nucleotide polymorphisms were analyzed for associations with the brain age groups.
Brain Alzheimer's Disease Cognitive Function Dementia Genetic Imaging Imaging Techniques Neurodegeneration Neurodegenerative Diseases Neuroimaging
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