Findings indicate stimulants and atomoxetine effectively reduce ADHD symptoms, though non-pharmacological therapies show potential for long-term efficacy.
By Tarun Sai LomteReviewed by Danielle Ellis, B.Sc.Dec 20 2024 Stimulants and atomoxetine emerge as most effective for core symptoms, but non-pharmacological therapies show promise in specific contexts and long-term data remains limited
Both pharmacological and non-pharmacological interventions are available for ADHD. Guidelines from the United Kingdom’s National Institute for Health and Care Excellence recommend non-pharmacological support if patients prefer it, medications are ineffective or poorly tolerated, or adherence to medicines is difficult. Given the concerns about the safety of ADHD medicines, gaining insights into the safety and efficacy of available ADHD interventions in adults is crucial.
Acceptability was defined as an all-cause discontinuation rate. Effect sizes were estimated from pairwise meta-analyses and network meta-analyses using odds ratios for dichotomous outcomes and standardized mean differences for continuous outcomes. Secondary symptoms were ADHD core symptom severity at around 26 weeks and 52 weeks, tolerability, emotional dysregulation, quality of life, and executive dysfunction.
Twenty-four RCTs compared active interventions, 16 of which did not include control conditions. No RCT on non-pharmacological interventions provided evidence that subjects were ineligible for pharmacological intervention. The team found that stimulants and atomoxetine were better than placebo in reducing the core symptoms of ADHD at around 12 weeks on both self- and clinician-rated scales.
When analyses were restricted to RCTs with a low risk of bias, bupropion, stimulants, and atomoxetine were more efficacious than placebo in reducing self-reported symptoms; atomoxetine was also less acceptable than placebo.
Bupropion Children Efficacy Hyperactivity Inattention Placebo Psychiatry
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Green Oil Massive Brush Review: A Comprehensive Insight into Its PerformanceThe Green Oil Massive Brush is meticulously reviewed for its performance in cleaning various bike components. While it excels in quick, effective cleaning for general bike parts, it falls short for heavily ingrained patina or drivetrains. The ergonomic design and sustainable materials make it a high-value choice despite the price.
Read more »
King David School Named North West Comprehensive of the YearKing David School in Liverpool has been named the North West comprehensive school of the year by the Sunday Times' Parent Power Guide 2025. The annual guide also recognized Birkenhead School as the region's independent secondary school of the year.
Read more »
Vitamin Malabsorption: A Comprehensive Guide from A to KMalabsorption disrupts vitamin absorption, leading to deficiencies in essential nutrients like A, D, E, K, C, and B12, with significant health implications.
Read more »
Mayo Clinic researchers advocate for comprehensive TPMT genotyping across ancestriesMayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or African American descent.
Read more »
CNIC team develops a comprehensive set of genetic tools and mouse linesA team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed a comprehensive set of innovative genetic tools and mouse lines, called iFlpMosaics, designed to enhance the study of gene function and its implications in health and disease.
Read more »
Monzo 'Wrapped' is back and people are red-faced with their findings'Your Year in Monzo' has now been released and shows users of the banking app their most frequented shops and purchases.
Read more »