Fibroblastic reticular cells (FRCs) create T-cell-supportive niches within lung cancer tumors, facilitating T-cell migration, clustering, and activation. This study highlights FRCs' potential as therapeutic targets to boost anti-tumor immunity in non-small cell lung cancer (NSCLC).
By Dr. Chinta SidharthanReviewed by Benedette Cuffari, M.Sc.Dec 1 2024 Discover how specialized cells form immune-boosting niches in lung tumors, unlocking new strategies to enhance cancer treatments and improve outcomes.
What are FRCs? The ability of the immune system to fight cancer relies on coordinated interactions between various immune cells and their specialized microenvironments. Although FRCs are well-studied in lymphoid tissues, their presence and role within tumors remain unclear. Thus, understanding how FRCs create T-cell-friendly environments within tumors is crucial to clarify the different mechanisms that may boost immunity and improve therapeutic responses. To date, there remains a lack of data on the origin, differentiation pathways, and specific contributions of FRCs to tumor immunity.
In vivo, studies in mice were subsequently conducted to monitor the differentiation of FRCs from perivascular progenitor cells through lineage-tracing methods. Thereafter, two distinct FRC subsets of perivascular reticular cells and T zone reticular cells were found to originate from adventitial and mural fibroblast populations.
In human NSCLC, CCL19-expressing FRCs were responsible for tertiary lymphoid structure formation and T-cell tracks. These structures facilitated T-cell clustering, which suggests enhanced immune interactions within the tumor microenvironment. Confocal microscopy also revealed CCL19 gradients along T-cell tracks that likely facilitate T-cell migration and activation.
Immunity Lung Cancer Bioinformatics CCL19 Cell Cell Migration Chemokine Chemokines Confocal Microscopy Coronavirus Immune System Immunotherapy Ligand Microscopy Molecule Non-Small Cell Lung Cancer Progenitor Cells Small Cell Lung Cancer T-Cell Tumor
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