T helper (TH) cells are essential immune cells that help other immune cells function effectively. When activated in response to environmental stimuli, these cells can differentiate into either TH1 cells, which fight against viruses and intracellular pathogens, or TH2 cells, which fight against extracellular pathogens like bacteria and parasites.
Brigham and Women's Hospital Nov 12 2024 Vijay K. Kuchroo, PhD, DVM, of the Gene Lay Institute of Immunology and Inflammationof Brigham and Women’s Hospital , Massachusetts General Hospital and Harvard Medical School and the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital , is the co-corresponding author of a paper published in Nature, “Neuropeptide signaling orchestrates T cell differentiation.
Our research has shown that virally infected neurons play a significant role by promoting the development of TH1 cells and inhibiting TH2 cells during viral infections. This communication between infected neurons and the immune system happens through molecules called neuropeptides, which interact with specific receptors on T cells to guide their fate. This process is crucial for the body to effectively control viral infections.
Related StoriesBy combining various gene and and cellular biology techniques, we demonstrated that the neuropeptide receptor RAMP3 plays a key role in how T cells develop using preclinical models. We showed that neuroimmune circuits, influenced by neuropeptides and theirreceptors, play a pivotal role in determining T cell fate. We also explored how neuropeptides ensure optimal T cell differentiation and drive robust antiviral responses.
Research Bacteria Covid-19 Hospital Intracellular Neurons
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