He went from 20st 5lbs to a phenomenal 14st 9lbs and he is now reaping the rewards of his hard work 👏🏼
A diabetic man from Glasgow has lost over five stone after receiving a scare during his annual visit to his GP. Derek Gray, 47, was told he could lose a limb by the time he was fifty if he didn't take control of his blood sugar and weight.
Derek has gone from a 44-inch waist to a 32-inch and his shirt size has dropped significantly from a 5XL to an XL. "My wife and sister-in-law encouraged me to join, and my sister-in-law also said she would go with me as she too was already a WW member. I had nothing to be embarrassed about, and the support from my family has been amazing.
Derek would often indulge in fatty junk foods and had takeaway meals for dinner at least five days a week. He wouldn't think twice about eating sweets, crisps and cakes.
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Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis - Journal of Biomedical ScienceBackground This work elucidates the first cellular and molecular causes of cataractogenesis. Current paradigm presupposes elevated blood glucose as a prerequisite in diabetic cataractogenesis. Novel evidence in our model of diabetic cataract challenges this notion and introduces immune cell migration to the lens and epithelial-mesenchymal transformation (EMT) of lens epithelial cells (LECs) as underlying causes. Methods Paucity of suitable animal models has hampered mechanistic studies of diabetic cataract, as most studies were traditionally carried out in acutely induced hyperglycemic animals. We introduced diabetic cataract in the Nile grass rat (NGR) that spontaneously develops type 2 diabetes (T2D) and showed its closeness to the human condition. Specialized stereo microscopy with dual bright-field illumination revealed novel hyperreflective dot-like microlesions in the inner cortical regions of the lens. To study immune cell migration to the lens, we developed a unique in situ microscopy technique of the inner eye globe in combination with immunohistochemistry. Results Contrary to the existing paradigm, in about half of the animals, the newly introduced hyper reflective dot-like microlesions preceded hyperglycemia. Even though the animals were normoglycemic, we found significant changes in their oral glucose tolerance test (OGTT), indicative of the prediabetic stage. The microlesions were accompanied with significant immune cell migration from the ciliary bodies to the lens, as revealed in our novel in situ microscopy technique. Immune cells adhered to the lens surface, some traversed the lens capsule, and colocalized with apoptotic nuclei of the lens epithelial cells (LECs). Extracellular degradations, amorphous material accumulations, and changes in E-cadherin expressions showed epithelial-mesenchymal transformation (EMT) in LECs. Subsequently, lens fiber disintegration and cataract progression extended into cortical, posterior, and anterior subcapsular catar
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