A prospective study found that 96% of patients with RA-ILD had at least one serious infection, which proved fatal in 65% of cases.
–associated interstitial lung disease have a high risk for serious and fatal infections, with age, inflammation, and corticosteroid therapy further increasing this risk.Patients with RA who have extra-articular manifestations such as ILD are highly susceptible to infections, but information on the types of infections, risk factors, and associations of infections with hospitalization and mortality is limited.
This prospective multicenter cohort study evaluated infections in a cohort of 148 patients with RA-ILD recruited from 11 university hospitals in Spain between March 2015 and March 2023. Joint, lung, and any infection-related variables were evaluated using clinical and laboratory evaluations at baseline and selected time points till the end of the follow-up period .
Researchers also investigated the common infectious sites, the etiology of the infection, vaccination status, variables associated with lung function, and clinical-therapeutic variables associated with RA.During the follow-up period, almost all patients had at least one infection, with the median time to first infection being 21.2 months and 65% of the deaths being directly related to infections.were the most common first infections and led to death in 80% of the patients.
RA - Rheumatoid Arthritis Rheumatoid Arthritis (RA) Skin And Soft Tissue Infection Urinary Tract Infection UTI - Urinary Tract Infection UTI Streptococcal Interstitial Lung Disease Lung Arthritis Joint Inflammation COVID-19 2019 Novel Coronavirus 2019-Ncov Wuhan Coronavirus Human Coronavirus HKU1 Human Coronavirus OC43 Hcov-OC43 Human Coronavirus 229E
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