How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors Coronavirus Disease COVID Genetics Environmental SARSCoV2 biorxivpreprint HKUniversity RockefellerUniv ugent waynestate institutpasteur
By Neha MathurNov 28 2022Reviewed by Benedette Cuffari, M.Sc. Severe acute respiratory syndrome coronavirus 2 -infected individuals display a wide range of clinical variations, from asymptomatic infection to lethal disease. In a recent study published on the bioRxiv* preprint server, and international team of researchers investigated the genetic, immunological, and evolutionary factors that determine the vast variability observed in clinical manifestations of the coronavirus disease 2019 .
For example, in East Asians, strong genetic adaptations starting about 25,000 years ago have been reported against multiple human coronavirus-interacting proteins. Furthermore, many examples of human adaptation to ribonucleic acid viruses as a source of population genetic differentiation have also been published.
The researchers also explored the contribution of natural selection to population differentiation of immune responses. To this end, they searched for overlaps between eQTLs or reQTLs and genome-wide signals of local adaptation that were measured by the population branch statistic . Study findings Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year. Download a copy today Cellular proportions that varied due to environmental exposures were the primary drivers of population differences in SARS-CoV-2 immune responses.
GBP7 also regulates IFN-γ-induced oxidative host defense conferring resistance to intracellular bacteria, such as Listeria monocytogenes and Mycobacterium tuberculosis, thereby providing a feasible mechanism for positive selection at this gene locus.
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