A study of fasting and the ketogenic diet reveals a new vulnerability of pancreatic tumors to an existing cancer drug.
University of California - San FranciscoAug 14 2024
The team made the discovery, which appears August 14 in Nature, while they were trying to figure out how the body manages to subsist on fat while fasting. They found that a new cancer drug called eFT508, currently in clinical trials, blocks eIF4E and the ketogenic pathway, preventing the body from metabolizing fat. When the scientists combined the drug with a ketogenic diet in an animal model of pancreatic cancer, the cancer cells starved.
Burning different fuels in the engine of the cell Humans can survive for weeks without food, in part because the body burns stored fat. By tracking how different metabolic pathways changed during fasting, the scientists discovered that eIF4E was activated by the presence of free fatty acids, which are released by fat cells early in fasting, so the body has something to consume.
The Achilles' heel of pancreatic cancer The scientists first treated pancreatic cancer with a cancer drug called eFT508 that disables eIF4E, intending to block tumor growth. Yet, the pancreatic tumors continued to grow, sustained by other sources of fuel like glucose and carbohydrates.
Cancer Therapy Diet Ketogenic Diet Pancreatic Cancer Fasting Glucose Liver Metabolism Metabolite Pharmacology Protein Research Translation Urology
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