Renowned neuroscientist Dr. Peter Kalivas discusses how brain circuits drive addictive behaviors and potential new drug targets for treating behavioral disorders.
In a comprehensive Genomic Press Interview published today in Brain Medicine, renowned neuroscientist Dr. Peter Kalivas reveals crucial insights into how brain circuits drive addictive behaviors and discusses potential new drug targets for treating behavioral disorders . Dr.
Kalivas, Distinguished University Professor at the Medical University of South Carolina, has transformed our understanding of addiction neuroscience through his pioneering work on the tetrapartite synapse - a complex cellular structure that includes neurons, astroglia, and the extracellular matrix. His research has revolutionized how we conceptualize addiction treatment by identifying novel therapeutic targets beyond traditional neurotransmitter systems. 'Scientific research is a personal art form, akin to painting or any other endeavor where the thrill of discovery and exploration energizes you,' Dr. Kalivas explains, reflecting on his research philosophy. 'The hierarchy within science was largely irrelevant to discovery; rather, it was more important to be embedded in a team of colleagues from technicians to students to Principal Investigators who have varied perspectives that could shape my research.' Dr. Kalivas's groundbreaking work on the tetrapartite synapse has revealed new perspectives on how the brain's cellular environment influences addictive behaviors. His research examines how astroglia and the extracellular matrix - components often overlooked in traditional neuroscience - play crucial roles in regulating synaptic activity, particularly in brain regions associated with reward and addiction – this is also known as the tetrapartite synapse. The field of addiction neuroscience has evolved far beyond simply studying neurotransmitters. We're now understanding how the entire cellular environment around synapses contributes to addictive behaviors. This opens up entirely new possibilities for therapeutic interventions
Addiction Neuroscience Brain Circuits Tetrapartite Synapse Drug Targets Behavioral Disorders
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