The news comes as the UK’s medicines regulator said donanemab could be licensed for use in the UK
A new Alzheimer’s drug has been rejected by the health spending watchdog for general use within NHS England, with the National Institute for Health and Care Excellence stating the treatment "does not currently demonstrate value for the NHS ".
"Our independent committee looked at all the available evidence, including the benefits for carers. This shows donanemab could slow down cognitive decline by four to seven months, but this is just not enough benefit to justify the additional cost to the NHS. The cost-effectiveness estimate for donanemab is five to six times above what Nice normally considers an acceptable use of NHS resources.
Nice said did not recommend donanemab for use on the NHS "as the benefits it offers patients are too small to justify the additional costs". Nice further added that there are "significant uncertainties to how much benefit donanemab provides, and how long this lasts for after stopping treatment". Clinical trials for donanemab, also known as Kisunla, demonstrated its ability to decelerate memory and cognitive decline by over 20%, with additional data suggesting a 40% reduction in the deterioration of daily activities such as driving, engaging in hobbies, and managing finances.
Hilary Evans-Newton, chief executive at Alzheimer’s Research UK, said: “Today’s announcement marks another frustrating setback for people affected by Alzheimer’s disease. “Today’s decision also risks signalling that the UK is no longer a good place to launch new dementia treatments.”
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