Preclinical drug evaluation, especially for cardiotoxicity, is a critical stage in the drug development process.
Chinese Academy of SciencesMar 11 2025 Traditional methods, often relying on in vitro assays or manual manipulation of animal models, are both inefficient and unable to fully mimic in vivo conditions. Zebrafish, with their transparent bodies, rapid development, and genetic similarities to humans, are emerging as a powerful model for high-throughput screening . However, the existing phenotyping techniques are labor-intensive and rely on anesthesia, which can compromise physiological responses.
A team of researchers from Sun Yat-sen University has responded to this challenge with the development of the Automated In Vivo Screening System . Published in Microsystems & Nanoengineering on January 27, 2025, the study showcases how the AISS can automate zebrafish larvae manipulation, allowing for precise, multi-organ imaging with minimal human intervention.
The AISS is designed to automate the entire process of zebrafish larvae handling. Using microfluidic chips, the system encapsulates individual larvae in droplets, enabling precise control over drug concentration gradients and real-time observation of organ responses. By eliminating the need for anesthesia, the system allows for high-resolution imaging of organs such as the heart, brain, and liver.
This automated screening system represents a major advancement in preclinical drug evaluation. By eliminating the need for anesthesia and manual manipulation, we can now observe real-time physiological responses in zebrafish with unprecedented precision. This system has the potential to transform how we screen for drug toxicity and efficacy, ultimately leading to safer and more effective pharmaceuticals.
Genetic Heart High-Throughput Screening Imaging In Vitro In Vivo Labor Laboratory Preclinical Research Technology
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