A new study published in the Journal of Biomedical Research reveals that medical ozone therapy effectively targets NETs (Neutrophil Extracellular Traps) and improves survival rates in mice with sepsis-induced ALI (Acute Lung Injury).
Sepsis, a severe and often fatal complication of infection, is a leading cause of both ALI and acute respiratory distress syndrome (ARDS). These conditions, which are associated with high mortality rates, remain challenging to treat due to the lack of effective therapies. NETs play a central role in the progression of sepsis, as they are involved in trapping pathogens but can also trigger excessive inflammation, exacerbating lung injury.
The complexity of sepsis-induced ALI, driven by the interplay among inflammation, immune dysregulation, and coagulation, calls for innovative therapeutic strategies to better manage this critical condition. In a study from Nanjing Medical University, researchers have made significant progress in this area. Published in the Journal of Biomedical Research on November 28, 2024, the study details how medical ozone therapy targets the AMPK/SR-A1 axis to effectively clear NETs, significantly improving survival rates and lung function in mice suffering from sepsis-induced ALI. This work represents a critical step forward in the search for new treatments for this deadly condition. The study provides an in-depth examination of the mechanisms behind ozone therapy's therapeutic effects on sepsis-induced ALI. Researchers discovered that ozone treatment reduced the formation of NETs, which was a key factor in the development of ALI. By activating the AMPK/SR-A1 pathway, ozone therapy enhanced the ability of macrophages to clear these harmful NETs, reducing inflammation and mitigating lung injury. The research also emphasizes the essential role of SR-A1: in knockout mice lacking SR-A1, ozone therapy failed to produce its protective effects, highlighting the receptor's critical role in mediating ozone's therapeutic impact
Sepsis ALI Ozone Therapy Nets AMPK/SR-A1 Axis
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Dual-antibody therapy shows promise in treating metastatic colorectal cancerMetastatic colorectal cancer (mCRC) remains a daunting challenge, especially after first-line treatments fail.
Read more »
Two NI based shows feature in New York Times Best TV Shows 2024 listThe popular shows have been praised as 'enthralling' and 'terrific' while tackling serious subjects
Read more »
Northern Ireland Shows Make New York Times Best TV Shows of 2024 ListTwo productions set in Northern Ireland, Say Nothing and Blue Lights, have been recognized by the New York Times in their Best TV Shows of 2024 list. Say Nothing, based on Patrick Radden Keefe's book, is noted for its enthralling narrative set during The Troubles, while Belfast-based Blue Lights features in the Best International Shows section.
Read more »
Study Reveals Both Enthusiasm and Caution Surrounding Psychedelic TherapyA new study published in the journal Psychedelics reveals complex attitudes toward psychedelic therapy. While participants showed strong support for potential benefits, they also acknowledged risks.
Read more »
Novel mRNA-based therapy offers hope for patients with proliferative vitreoretinopathy Mass Eye And Ear-Le...A new preclinical study by Mass Eye and Ear investigators showed that a novel mRNA-based therapy may be able to prevent blindness and scarring from proliferative vitreoretinopathy (PVR) following a retinal detachment repair or traumatic injury to the eye.
Read more »
– Here Are 5 Reasons Why Therapy Didn't Work For YouDr Madeleine Jago is the Principal Clinical Psychologist and founder of Seven Lion Yard. Seven Lion Yard is a holistic health and wellbeing centre in Clapham offering psychological therapies to children, families and individuals and group classes in mindfulness, meditation and breath work.
Read more »