A new approach to targeting a protein involved in cell division, which can misfunction in cancer, has revealed new insights into how it functions.
University of BirminghamDec 3 2024
Aurora-A is of particular interest as a target for anti-cancer drugs because of its role in cell division. Although numerous clinical trials of drugs designed to inhibit Aurora-A have been undertaken, none have progressed into clinical use. This is because Aurora A has an essential role in all cells and so undesirable toxicity is common.
Aurora-A is an incomplete kinase, which means it relies on protein-protein interactions to regulate where it is in the cell and when it is switched on and off. By targeting these interactions, we might be able to more finely tune how we inhibit Aurora-A." The team sought to inhibit the interaction of Aurora A with a protein called TACC3 using a peptidomimetic approach.
Drug Discovery Protein Cell Cell Division Drugs Kinase Research
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