Phenotyping the rNLS8 mouse model shows promise to help develop new drugs for ALS.
Sponsored Content by Charles River Labs - Neuroscience Discovery ServicesDec 9 2024 This article is based on a poster originally authored by Jussi Toivanen, Yajuvinder Singh, Leena Rauhala, Taina-Kaisa Stenius, Kimmo Lehtimäki, and Susanne Bäck.
Methods Animals: All animal work followed the European Union Directive 2010/63 and was approved by the national Project Authorization Board. Mice lacking the tetO-hTDP-43-ΔNLS transgene were compared to hemizygous rNLS8 double transgenic mice . Figure 2. Weakness symptoms and body weight over time. A) Clinical scores as assessed thrice per week, * p < 0.05 . B) Body weights measured thrice per week. Mean±SEM. * p < 0.05 . tTA, n=6F+6M; rNLS8, n=6F+10M. The red line indicates the timing of dox diet discontinuation. Image Credit: Charles River Laboratories.
Figure 4. NfL levels in the CSF. Mean±SEM. **** p < 0.0001, Welch’s t-test. tTA, n=5F+6M, rNLS, n=6F+10M. Image Credit: Charles River Laboratories. TPD-43 pathology: In the spinal cords of rNLS8 animals, the total intensity of TPD-43 staining rose significantly. TDP-43 levels were also much lower in the nucleus than in the cytoplasm showing mislocalisation of this protein. Enhanced phosphorylation of the protein was observed .
About Charles River Laboratories At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guides us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe.
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Largest ALS patient-based iPSC repository opens new frontiers in researchIn a landmark continuing collaboration, Answer ALS and Cedars-Sinai have announced the completed availability of the largest amyotrophic lateral sclerosis (ALS) patient-based induced pluripotent stem cell (iPSC) and bio data repository.
Read more »
‘I was told I had five years left to live in 1993’Naima Chakkour is one of the world’s longest survivors of Motor Neurone Disease (MND, also known as ALS) and shares her story with Metro.
Read more »
Village People singer defends Trump's use of ‘Y.M.C.A.,' says song isn't a ‘gay anthem'Victor Willis said the disco classic has “benefited greatly” from the president-elect’s use.
Read more »
Rebranded Jaguar sparks further backlash after teasing new car model akin to ‘Tesla Cybertruck’Jaguar has sparked further backlash after it teased a new car model akin to the 'Tesla Cybertruck'.
Read more »
– Bottega Veneta and Flos release a special edition of the Model 600Hugo is a design critic, curator and the co-founder of Bard, a gallery in Edinburgh dedicated to Scottish design and craft. A long-serving member of the Wallpaper* family, he has also been the design editor at Monocle and the brand director at Studioilse, Ilse Crawford's multi-faceted design studio.
Read more »
Reimagining axons with the pearls-on-a-string modelIn a provocative new study, scientists challenge a fundamental tenet in neuroscience about the shape of axons -- the long, thin filaments radiating from nerve cells that transmit electrical signals from cell to cell – and propose a new model for understanding how information is transmitted in the brain.
Read more »