Albumin is a major prognostic factor for patients with advanced liver disease, dependent on its concentration and biological activity.
Xia & He Publishing Inc.Oct 29 2024 Background and objectives This study aimed to improve the method of active albumin detection and elucidate its predictive validity of albumin activity across hepatic disease progression and etiology.
Methods This study synthesized a novel ratiometric fluorescent probe with an improved structure of 2′-FBPBN. The technique was used to detect native human albumin activity in 244 patients with hepatitis B cirrhosis and 66 patients with hepatocellular carcinoma . Clinical and laboratory data were also collected.
Results Patients with LC and HCC were divided into normal albumin and low albumin groups. The median levels of albumin and HA activity in LC patients were 41.44 g/L and 51.85%, 28.51 g/L and 53.89%, respectively, while in HCC patients, they were 43.19 g/L and 33.69%, 30.77 g/L and 43.63%, respectively.
Conclusions Native HA activity may outperform albumin as a prognostic indicator for assessing the severity of liver disease.Journal reference:Liu, X., et al. . A Novel Probe Technology for Detecting Native Albumin Activity as a Biomarker in Patients with Hepatitis B-related Cirrhosis and Hepatocellular Carcinoma and Its Clinical Applications. Future Integrative Medicine. doi.org/10.14218/fim.2024.00022.
Biomarker Cirrhosis Hepatitis Hepatitis B Technology Carcinoma Hepatocellular Carcinoma Liver Liver Disease Medicine
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