The only infection risk in patients with RA that is higher with Janus kinase inhibitors relative to biologics is herpes zoster, according to pooled registry data.
Real-World RA Data Find JAK Inhibitor Infection Risk Is Low and No Greater Than Other DMARDs, Other Than Herpes Zoster VIENNA — In patients with rheumatoid arthritis , Janus kinase inhibitors are associated with a substantially greater risk for herpes zoster , but the risk for other types of infections is about the same and often numerically lower relative to biologic disease-modifying antirheumatic drugs , according...
"It is nice to have data indicating that risk of other infections is no higher with JAKi than other treatment options, but I am not sure this has been a big concern," he said."But I do think more information about other types of risks would be helpful."Although the greater risk for herpes zoster with JAKi vs bDMARDs is well established, the relative risk for other types of infections has been unclear, according to Aymon.
Other characteristics such as disease activity, body mass index, and percentage of smokers were comparable. Based on a Poisson regression analysis, this study took into account a wide variety of variables, including age, disease activity, comorbidities, and tobacco use, Aymon said. He noted that the analyses were performed on data from each registry as well as with the pooled data, and the data were reasonably consistent.
RA - Rheumatoid Arthritis Rheumatoid Arthritis (RA) Herpes Zoster Shingles Jak/Stat Jak-Stat Signaling Pathway Jak-Stat Cytokine Receptors Disease-Modifying Antirheumatic Drugs Dmards DMARD Tobacco Tobacco Use Biologic Therapy Biologics Antineoplastic Drug Anti-Cancer Agents Erlotinib Gefitinib Imatinib Rituximab Su11248 Sunitinib Trastuzumab Arthritis
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