Adults with heart failure with reduced ejection fraction (HFrEF) who took a 'polypill' combining medications prescribed for the treatment of heart failure, had improved heart function and symptoms, better quality of life, fewer hospitalizations and greater medication adherence than those taking the medications individually, according to a...
American Heart AssociationNov 10 2025 Adults with heart failure with reduced ejection fraction who took a "polypill" combining medications prescribed for the treatment of heart failure , had improved heart function and symptoms, better quality of life, fewer hospitalizations and greater medication adherence than those taking the medications individually, according to a late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.
The meeting, Nov. 7-10, in New Orleans, is a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science. In recent decades, there have been important, effective treatment advances for patients with heart failure, however, use of these treatments remains disappointingly low, with only 15% of patients receiving all guideline-recommended therapies at any dose for heart failure after hospitalization. In our study, we focused on socially disadvantaged populations to demonstrate the positive impact of an easier-to-follow medication regimen of only one pill vs. three pills daily, and we found significant improvements even after six months. Our findings provide the first evidence that a polypill approach could be effective for our patients with heart failure." Ambarish Pandey, M.D., M.S., FAHA, study author, associate professor of internal medicine, division of cardiology and geriatrics at UT Southwestern Medical Center in Dallas and medical director of the center's heart failure with preserved ejection fraction program The trial included 212 adults with HFrEF who were not receiving guideline-recommended treatment. Participants were randomly assigned to one of two groups: 108 participants were prescribed the polypill regimen, which included metoprolol succinate , spironolactone and empagliflozin . The second group of 104 adults were assigned to enhanced standard care, taking guideline-recommended medications as individual pills. Everyone also took an angiotensin receptor-neprilysin inhibitor , sacubitril-valsartan, which is dosed twice-daily and not well suited for a once-daily polypill.Related StoriesThe study group plans more research on how best to address heart failure in specific groups. "Moving forward, we are planning additional studies to evaluate broader implementation of the polypill approach in heart failure," Pandey said.According to the American Heart Association, heart failure is a serious, long-term condition. It's more likely to happen as you age, but anyone can get it. Heart failure cases have been rising in the U.S. due in part to the aging population. About 6.7 million adults in the U.S. are living with heart failure-and expected to increase to more than 8 million by 2030. Heart failure with reduced ejection fraction means the individual's ejection fraction is equal to or less than 40%, indicating percentage of blood that leaves the left ventricle with each heartbeat. Left ventricular ejection fraction is a metric typically used in heart failure assessments, as it defines the percentage of blood pumped from the left ventricle of the heart to the other organs in the body.
Heart Failure Blood CT Hospital Medication Adherence Receptor Research
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