The formation of aggregates due to protein misfolding and resulting protein instability is associated with several diseases. Previous studies have shown the potential of sulfobetaine polymer, a zwitterionic polymer, to suppress protein aggregation.
Understanding how zwitterionic polymers can lead to safer drugs and disease prevention." ScienceDaily. ScienceDaily, 30 May 2024. <www.sciencedaily.comJapan Advanced Institute of Science and Technology. . Understanding how zwitterionic polymers can lead to safer drugs and disease prevention.Japan Advanced Institute of Science and Technology."Understanding how zwitterionic polymers can lead to safer drugs and disease prevention." ScienceDaily. www.sciencedaily.
Many neurodegenerative diseases, such as dementia, are characterized by the abnormal aggregation of proteins inside cells, and treatments are being developed to break them up. But new research ... Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail. ...
Using a new method 'Terahertz calorimetry', a research team shed new light on the spontaneous phase separation into a protein-rich and a protein-poor phase in a solution. It is assumed that the ... The aggregation of amyloid protein fibrils is involved in diseases such as amyloidosis and even Alzheimer's. Thus, dissociation of these amyloid fibrils is crucial from a biological perspective. ...
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