Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic target.
Durham UniversityNov 26 2024 Research ers from Durham University, Jagiellonian University and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic target.
Unlike a band that would unwind if released, DNA gyrase stabilises DNA's twisted form, making it functional for bacteria. Using state-of-the-art cryo-electron microscopy, the team captured a snapshot of gyrase at work, revealing how it wraps DNA through outstretched protein arms to form the figure-of-eight shape.
DNA Enzyme Bacteria Electron Electron Microscopy Microscopy Research Supercoiling
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