What is currently known about the potential effect of vitamin D (VitD) on modulating some hallmarks of aging.
By Priyanjana Pramanik, MSc.Mar 26 2024Reviewed by Lily Ramsey, LLM In a recent review article published in Nutrients, researchers summarized what is currently known about the potential effect of vitamin D on modulating some hallmarks of aging and age-related diseases.
In the case of mammals, these are dysbiosis, chronic inflammation, intercellular communication alternations, exhaustion of stem cells, cellular senescence, mitochondrial dysfunction, nutrient sensing deregulation, disabled macroautophagy, proteostasis loss, epigenetic alterations, telomere attrition, and genomic instability.
After liver processing, it converts into calcitriol, the active form. Calcitriol regulates calcium and phosphorus homeostasis by binding to the VitD receptor . Beyond bone health, VitD has immunomodulatory functions and affects mitochondrial bioenergetics. Related StoriesStudies suggest VitD supplementation may reduce DNA damage and oxidative parameters, potentially offering protective effects against genomic instability and oncogene-induced senescence.
Trials with nutraceutical supplements and alphacalcidol demonstrate improved immune profiles in older adults, underscoring VitD's immunomodulatory role in aging and chronic inflammation. VitD also shows potential in mitigating mitochondrial dysfunction in conditions like sarcopenia and Crohn's disease.
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