What role do dietary lipids play in the gut-brain axis in type 2 diabetes mellitus? BioMedCentral diet dietarylipids lipids health t2d type2diabetes T2D gutbrainaxis nutrition news
By Bhavana KunkalikarApr 4 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Journal of Translational Medicine, researchers examined the significance of dietary lipids in the gut-brain axis of individuals with type 2 diabetes mellitus .
Enhancing comprehension of the functions of certain nutrients in T2DM via interactions with gut microbiota will facilitate the formulation of novel approaches for the prevention and management of T2DM. Dietary lipids and the gut-brain axis in T2DM Several dietary fatty acids are absorbed within the small intestine, while a subset of these fatty acids directly impacts the composition of the microbiota within the colon.
Similarly, it has been noted that the proliferation of Desulfovibrio bacteria exhibits opportunistic pathogenicity and generates LPS among mice subjected to high-fat diets. LPS is transported into the systemic circulation, leading to the subsequent release of interleukins. Omega-3 fatty acids can also impede proinflammatory cytokine production in human blood monocytes. Additionally, they can mitigate intestinal inflammation. Omega 3 fatty acid administration in Salmonella-infected mice resulted in an increase in SFA levels, modification of the gut microbiota, and reinforcement of resistance of the host to pathogens.
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