A new study using PSMA-PET imaging found that many high-risk prostate cancer cases previously classified as nonmetastatic may actually have spread beyond the initial location. This highlights the importance of advanced imaging in accurately staging prostate cancer and informing treatment decisions.
A new study from the UCLA Health Jonsson Comprehensive Cancer Center reveals that many cases of high-risk nonmetastatic hormone-sensitive prostate cancer may be more advanced than initially diagnosed.
Published in JAMA Network Open, the study found that nearly half of high-risk prostate cancer patients previously classified as nonmetastatic using conventional imaging actually have metastatic disease when assessed with advanced prostate-specific membrane antigen–positron emission tomography (PSMA-PET) imaging. This suggests that traditional imaging methods may underestimate the extent of cancer spread in many instances. Senior author Dr. Jeremie Calais, director of the Ahmanson Translational Theranostics Division's clinical research program and associate professor at the department of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA, emphasized the importance of PSMA-PET in accurately staging prostate cancer, stating, 'Our study demonstrates the critical role of PSMA-PET in accurately staging prostate cancer, which can significantly impact treatment decisions and outcomes.' PSMA-PET imaging utilizes tiny amounts of radioactive 'tracers,' called radiotracers, that bind to prostate cancer cells, making them visible on PET scans. Unlike conventional imaging, which provides only anatomical details, PSMA-PET offers functional imaging that reveals the cancer's biological activity, leading to a more accurate staging of the disease. While the clinical adoption of PSMA-PET has transformed prostate cancer imaging, treatment decisions often rely on clinical trials that did not include this advanced imaging technique for patient selection
Prostate Cancer PSMA-PET Imaging Metastasis Treatment
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